Competitive hydrogen bonding of cyclopropenium ions: Implications of an anion switch

This work demonstrates how modulating hydrogen bonding between intermolecular, bifurcated, and intramolecular interactions can be used to tune the structural, electronic, and photophysical properties of cyclopropenium ions and their respective fluorophores. The basis of this switchability was examined using X-ray diffraction analysis, ¹H NMR spectroscopy, DFT calculations, and fluorescence spectroscopy.     

Fano profile in a novel double cavity optomechanical system with harmonically bound mirrors

We investigate a double cavity optomechanical system generating single and double Fano resonance (multi-Fano). By altering a single parameter, the tunnelling rate g of the middle mirror, we are able to switch between single and double Fano line shapes. The first spectral line shape is stronger in the case of multi-Fano than in the case of single Fano. Also the behaviour of the steady state value of the displacement of the middle mirror, with respect to g, heavily influences the behaviour of double Fano lines in our scheme. This tunability along with using a single pump and signal/probe laser has an added advantage in situations where only low power consumption is available.     

Luminescence Switching of Organogold(I) Complexes between Aggregation-induced Phosphorescence Enhancement and Aggregation-caused Quenching by Balancing Auxiliary Ligands around the AuI Center

Attaching AIE-active L1 ([1,1′:2′,1′′:4′′,1′′′-quaterphenyl]-2-yldiphenylphosphane) to AuCl, shortened the distances of P−C bonds to promote electron cloud overlap between Au^I and L1 , affords 1 ( L1 AuCl) with aggregation-induced phosphorescence enhancement (AIPE) activity by ³LMCT transitions. Then substituting the coplanar L2 (9-ethynylanthracene) for the Cl⁻ in 1 providing 2 , switches the luminescence to aggregation-caused quenching (ACQ) activity. Furthermore, we restore the performance from ACQ to AIPE by metathesis reactions to transfer 2 into 1 . It is versatile synthetic strategy of reversible transformation between 1 and 2 that switches the luminescence of organogold(I) between AIPE and ACQ through balancing auxiliary ligands around the given metal.     

FLTD三电极场畸变气体开关寿命特性

针对设计的一种场畸变气体开关,研究中间电极材料分别为不锈钢和黄铜条件下的烧蚀特性,结合开关寿命期间静态与触发特性的变化规律,获得决定开关寿命的关键因素,为三电极场畸变气体开关的性能优化提供理论支撑。研究结果表明,采用不锈钢和黄铜作为中间电极的烧蚀区域以及表面粗糙度均随着放电次数增加而增大,黄铜电极烧蚀较为严重且表面有明显的烧蚀圆斑,不锈钢电极则具有更高的表面粗糙度,阴阳极表面烧蚀存在明显差异,随着放电次数的增加,击穿点向电极边缘区域集中,影响开关的沿面绝缘特性,是导致开关寿命终结的主要原因。     

Switching the Switch: Ligand Induced Disulfide Formation in HDAC8

Human histone deacetylase 8 is a well-recognized target for T-cell lymphoma and particularly childhood neuroblastoma. PD-404,182 was shown to be a selective covalent inhibitor of HDAC8 that forms mixed disulfides with several cysteine residues and is also able to transform thiol groups to thiocyanates. Moreover, HDAC8 was shown to be regulated by a redox switch based on the reversible formation of a disulfide bond between cysteines Cys₁₀₂ and Cys₁₅₃. This study on the distinct effects of PD-404,182 on HDAC8 reveals that this compound induces the dose-dependent formation of intramolecular disulfide bridges. Therefore, the inhibition mechanism of HDAC8 by PD-404,182 involves both, covalent modification of thiols as well as ligand mediated disulfide formation. Moreover, this study provides a deep molecular insight into the regulation mechanism of HDAC8 involving several cysteines with graduated capability to form reversible disulfide bridges.     

FHIT-Substrate Complexes: a New Paradigm in Reversible Protein Phosphorylation

Fhit is a tumor suppressor protein encoded at the most fragile site in the human genome that is inactivated by genetic deletions early in the development of many cancers. A member of the Histidine Triad (HIT) superfamily of nucleotide-binding proteins, Fhit binds diadenosine triphosphate (ApppA) and cleaves it to produce AMP + ADP. The His96Asn mutation of Fhit, which reduces k_cat by more than a million-fold, does not reduce tumor suppressor activity in a nude mouse assay. Thus, genetic and biochemical evidence suggest that ApppA binding but not cleavage is required for tumor suppression. Crystal structures of Fhit bound to a nonhydrolyzable ApppA analog revealed that Fhit binds two substrates per dimer, presenting all of the phosphates and two of the adenosines on the surface of the protein in place of a deep, positively charged groove in the empty Fhit protein dimer. It is proposed that signaling by Fhit is mediated by presentation of nucleotide substrates to cytosolic effectors.     

Delayed stability switches in singularly perturbed predator–prey models

In this paper we provide an elementary proof of the existence of canard solutions for a class of singularly perturbed planar systems in which there occurs a transcritical bifurcation of the quasi steady states. The proof uses the one-dimensional result proved by V.F. Butuzov, N.N. Nefedov and K.R. Schneider, and an appropriate monotonicity assumption on the vector field. The result is applied to identify all possible predator–prey models with quadratic vector fields allowing for the existence of canard solutions.     

Helical Biphenyl Bisazo Polyurethane: Preparation,Characterization and Analysis of Polymeric Thermo-Optic Switch

The bisazo chromophore molecule (CAAPM) and helical biphenyl bisazo polyurethane (HBBPU) were synthesized. The structures of CAAPM and HBBPU were characterized by FT-IR and UV-vis spectroscopic techniques. The measurements of refractive index and thermo-optic coefficient (dn/dT) of HBBPU were demonstrated at different wavelengths and different temperatures by the ATR technique. By using CCD digital imaging devices, transmission loss of the internal waveguide was measured. The refractive index dispersions and Sellmeyer coefficients of HBBPU were obtained by the Sellmeyer equation. A Y-branched switch based on the thermo-optic effect was proposed and the performance of the switch was simulated. With a branching angle of 0.143° and the FD-BPM method, the result showed that the power consumption of the thermo-optic switch could be only 3.6 mW, and the response time of the switch could reach about 8 ms. This is a significant improvement in reducing power consumption compared with the normal Y-branched polymer thermo-optic switch.     

基于单片机和光电开关的通用计数器设计

At presrent, the photoelectric switch is more and more widely used in the industrial automation equipment.It can be finished counting industrial products by using the characteristic of the photoelectric switch which can detect the objects without touching them. This design uses the modular design method,including power-supply module, The photoelectric conversion module, optocoupler isolation circuit module, power off protection module, matrix keyboard module, counting module and The display module. It mainly uses 51 single-chip microcomputer to control the system,uses the keilC51 software to design program,uses the Proteus software to complete the simulation. Through the experiment, it proves the design is feasible.